Abstract
Cinnamyl derivatives of thieno[2,3-d]oxazinones are mechanism-based inhibitors of the HSV-2, VZV and CMV herpes proteases which demonstrate nanomolar potency. Compounds 5 and 28 inhibit protease processing in HSV-2 infected cells with a selectivity index of at least 30.
MeSH terms
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Antiviral Agents / chemistry
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Antiviral Agents / pharmacology*
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Cell Line
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Herpesviridae / enzymology*
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Oxazines / chemistry
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Oxazines / pharmacology*
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Protease Inhibitors / chemistry
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Protease Inhibitors / pharmacology*
Substances
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Antiviral Agents
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Oxazines
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Protease Inhibitors